H2N2V1, Main, Exploration, bibRecord, 001961

Avian influenza virus intranasally inoculated infects the central nervous system of mice through the general visceral afferent nerve

Identifieur interne : 001961 ( Main/Exploration ); précédent : 001960; suivant : 001962

Avian influenza virus intranasally inoculated infects the central nervous system of mice through the general visceral afferent nerve

Auteurs : K. Shinya ; A. Shimada ; T. Ito ; K. Otsuki ; T. Morita ; H. Tanaka ; A. Takada ; H. Kida ; T. Umemura

Source :

Archives of Virology [ 0304-8608 ] ; 2000-01-01.

RBID : ISTEX:1793703517F2A2FD307D787E50DD0AEECCC9CC87

Abstract

Summary.: To define the route of influenza virus invasion into the central nervous system (CNS), an avian influenza A (H5N3) virus was inoculated into mice intranasally or intravenously. Only the intranasal infection group mice showed depression and retention of gas in the digestive system. Pathological findings in the animals were bronchointerstitial pneumonia and non-suppurative encephalitis restricted to the brain stem. The nerve nucleus primarily affected was the nucleus of solitary tract. Prior to the development of the CNS lesions, viral antigen was detected in vagal and trigeminal ganglia. These results suggest that the primarily replicated virus in the respiratory mucosa ascended to the CNS via sensory nerve routes, inducing lesions in the brain stem, and then spread trans-synaptically in the CNS.

Url:

https://api.istex.fr/ark:/67375/VQC-NJF4MVK9-C/fulltext.pdf

DOI: 10.1007/s007050050016

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000B66
to stream Istex, to step Curation: 000B66
to stream Istex, to step Checkpoint: 000776
to stream Main, to step Merge: 001A04
to stream Main, to step Curation: 001961

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Avian influenza virus intranasally inoculated infects the central nervous system of mice through the general visceral afferent nerve</title>
<author><name sortKey="Shinya, K" sort="Shinya, K" uniqKey="Shinya K" first="K." last="Shinya">K. Shinya</name>
</author>
<author><name sortKey="Shimada, A" sort="Shimada, A" uniqKey="Shimada A" first="A." last="Shimada">A. Shimada</name>
</author>
<author><name sortKey="Ito, T" sort="Ito, T" uniqKey="Ito T" first="T." last="Ito">T. Ito</name>
</author>
<author><name sortKey="Otsuki, K" sort="Otsuki, K" uniqKey="Otsuki K" first="K." last="Otsuki">K. Otsuki</name>
</author>
<author><name sortKey="Morita, T" sort="Morita, T" uniqKey="Morita T" first="T." last="Morita">T. Morita</name>
</author>
<author><name sortKey="Tanaka, H" sort="Tanaka, H" uniqKey="Tanaka H" first="H." last="Tanaka">H. Tanaka</name>
</author>
<author><name sortKey="Takada, A" sort="Takada, A" uniqKey="Takada A" first="A." last="Takada">A. Takada</name>
</author>
<author><name sortKey="Kida, H" sort="Kida, H" uniqKey="Kida H" first="H." last="Kida">H. Kida</name>
</author>
<author><name sortKey="Umemura, T" sort="Umemura, T" uniqKey="Umemura T" first="T." last="Umemura">T. Umemura</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:1793703517F2A2FD307D787E50DD0AEECCC9CC87</idno>
<date when="2000" year="2000">2000</date>
<idno type="doi">10.1007/s007050050016</idno>
<idno type="url">https://api.istex.fr/ark:/67375/VQC-NJF4MVK9-C/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000B66</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000B66</idno>
<idno type="wicri:Area/Istex/Curation">000B66</idno>
<idno type="wicri:Area/Istex/Checkpoint">000776</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000776</idno>
<idno type="wicri:doubleKey">0304-8608:2000:Shinya K:avian:influenza:virus</idno>
<idno type="wicri:Area/Main/Merge">001A04</idno>
<idno type="wicri:Area/Main/Curation">001961</idno>
<idno type="wicri:Area/Main/Exploration">001961</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Avian influenza virus intranasally inoculated infects the central nervous system of mice through the general visceral afferent nerve</title>
<author><name sortKey="Shinya, K" sort="Shinya, K" uniqKey="Shinya K" first="K." last="Shinya">K. Shinya</name>
<affiliation><wicri:noCountry code="subField">JP</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Shimada, A" sort="Shimada, A" uniqKey="Shimada A" first="A." last="Shimada">A. Shimada</name>
<affiliation><wicri:noCountry code="subField">JP</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ito, T" sort="Ito, T" uniqKey="Ito T" first="T." last="Ito">T. Ito</name>
<affiliation><wicri:noCountry code="subField">JP</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Otsuki, K" sort="Otsuki, K" uniqKey="Otsuki K" first="K." last="Otsuki">K. Otsuki</name>
<affiliation><wicri:noCountry code="subField">JP</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Morita, T" sort="Morita, T" uniqKey="Morita T" first="T." last="Morita">T. Morita</name>
<affiliation><wicri:noCountry code="subField">JP</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Tanaka, H" sort="Tanaka, H" uniqKey="Tanaka H" first="H." last="Tanaka">H. Tanaka</name>
<affiliation><wicri:noCountry code="subField">JP</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Takada, A" sort="Takada, A" uniqKey="Takada A" first="A." last="Takada">A. Takada</name>
<affiliation><wicri:noCountry code="subField">JP</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kida, H" sort="Kida, H" uniqKey="Kida H" first="H." last="Kida">H. Kida</name>
<affiliation><wicri:noCountry code="subField">JP</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Umemura, T" sort="Umemura, T" uniqKey="Umemura T" first="T." last="Umemura">T. Umemura</name>
<affiliation><wicri:noCountry code="subField">JP</wicri:noCountry>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Archives of Virology</title>
<title level="j" type="abbrev">Arch. Virol.</title>
<idno type="ISSN">0304-8608</idno>
<idno type="eISSN">1432-8798</idno>
<imprint><publisher>Springer-Verlag</publisher>
<pubPlace>Wien</pubPlace>
<date type="published" when="2000-01-01">2000-01-01</date>
<biblScope unit="volume">145</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="187">187</biblScope>
<biblScope unit="page" to="195">195</biblScope>
</imprint>
<idno type="ISSN">0304-8608</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0304-8608</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Summary.:  To define the route of influenza virus invasion into the central nervous system (CNS), an avian influenza A (H5N3) virus was inoculated into mice intranasally or intravenously. Only the intranasal infection group mice showed depression and retention of gas in the digestive system. Pathological findings in the animals were bronchointerstitial pneumonia and non-suppurative encephalitis restricted to the brain stem. The nerve nucleus primarily affected was the nucleus of solitary tract. Prior to the development of the CNS lesions, viral antigen was detected in vagal and trigeminal ganglia. These results suggest that the primarily replicated virus in the respiratory mucosa ascended to the CNS via sensory nerve routes, inducing lesions in the brain stem, and then spread trans-synaptically in the CNS.</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Ito, T" sort="Ito, T" uniqKey="Ito T" first="T." last="Ito">T. Ito</name>
<name sortKey="Kida, H" sort="Kida, H" uniqKey="Kida H" first="H." last="Kida">H. Kida</name>
<name sortKey="Morita, T" sort="Morita, T" uniqKey="Morita T" first="T." last="Morita">T. Morita</name>
<name sortKey="Otsuki, K" sort="Otsuki, K" uniqKey="Otsuki K" first="K." last="Otsuki">K. Otsuki</name>
<name sortKey="Shimada, A" sort="Shimada, A" uniqKey="Shimada A" first="A." last="Shimada">A. Shimada</name>
<name sortKey="Shinya, K" sort="Shinya, K" uniqKey="Shinya K" first="K." last="Shinya">K. Shinya</name>
<name sortKey="Takada, A" sort="Takada, A" uniqKey="Takada A" first="A." last="Takada">A. Takada</name>
<name sortKey="Tanaka, H" sort="Tanaka, H" uniqKey="Tanaka H" first="H." last="Tanaka">H. Tanaka</name>
<name sortKey="Umemura, T" sort="Umemura, T" uniqKey="Umemura T" first="T." last="Umemura">T. Umemura</name>
</noCountry>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001961 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001961 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:1793703517F2A2FD307D787E50DD0AEECCC9CC87
   |texte=   Avian influenza virus intranasally inoculated infects the central nervous system of mice through the general visceral afferent nerve
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration H2N2

Avian influenza virus intranasally inoculated infects the central nervous system of mice through the general visceral afferent nerve

Avian influenza virus intranasally inoculated infects the central nervous system of mice through the general visceral afferent nerve

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri